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PROS Polio Immunization Delivery Study (PIDS)

Impact of the change to Inactivated Poliovirus Vaccine
on the immunization status of young children in the United States


PROS Pearls:

* This study examined if the change from an all-OPV poliovirus vaccine schedule to an IPV-containing schedule has adversely affected the immunization status of young children in the United States.

* There is no indication that the switch from an all-OPV to an IPV- containing immunization schedule has had any negative impact on the immunization status of young children in the US. Patients receiving IPV as the initial dose of poliovirus vaccine were at least as likely as those receiving OPV to be fully immunized at 8 months, 12 months and 19 months of age. This was true for the entire study population, all minority children and African-American patients.

* At 8 months of age, 79.4% of study children were fully immunized (3 DTP, 2 polio, 2 hib, and 2 Hepatitis B vaccines). A total of 3995 patients (56%) received an initial dose of OPV while 2445 (34%) received IPV; 725 children had received at least 1 poliovirus vaccine, but the particular type could not be determined.

* There was a rapid changeover from OPV to IPV among PROS and NMA providers. Prior to 1997 fewer than 12% of the initial doses of poliovirus vaccine administered were IPV. By the end of 1997, >70% of initial doses were IPV.


For the main part of the project, data were collected between March 1998 and December 1999; immunization information was obtained on over 13,000 children, aged 8 - 35 months, in 174 practices. Immunization data were abstracted from the medical records of children, 8- 35 months old, seen consecutively for any reason in the offices of practicing pediatricians who are members of the Pediatric Research in Office Settings (PROS) network of the American Academy of Pediatrics (AAP) or the National Medical Association (NMA). The PROS/NMA Polio Immunization Delivery Study (PIDS) was funded by the Centers for Disease Control and Prevention and the Health Resources and Services Administration Maternal and Child Health Bureau.

The following poster based on study results was presented at the 2000 Pediatric Academic Societies Meeting:

Taylor JA, Darden PM, Brooks DA, Baker AE. The impact of the change to IPV on the immunization status of children in the United States: A study from PROS and the National Medical Association (NMA). Accepted for poster presentation at the 2000 Pediatric Academic Societies Meeting.

The following item based on study results recently appeared in Pediatrics electronic pages:

Taylor JA, Darden PM, Brooks DA, Hendricks JW, Baker AE, Bocian AB, Rohder K, Wasserman RC. Impact of the change to Inactivated Poliovirus Vaccine on the immunization status of young children in the United States: A study from PROS and the National Medical Association. Pediatrics electronic pages 2001; 107(6):e90.


Manuscript writing continues.




Core support for the PROS network is provided by a grant from the Health Resources and Services Administration Maternal and Child Health Bureau

About PROS | Study Updates | Join PROS | Network News Excerpts
PROS Bibliography | Funding Sources | PROS Home Page

Pediatric Research in Office Settings (PROS)
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